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Diverticulosis patients are often told to avoid seeds and nuts because small food particles will get stuck in the crevices of their colon and cause diverticulitis. But that may not be true. Chris and Sophie debunk this oft repeated piece of advice for a disase that Sophie never heard of until today.   *** JOIN OUR STUDY: *** bit.ly/digitaldietstudy   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected].   Hosts:     Christopher Labos & Sophie Tseng Pellar Editor:    Robyn Flynn Researcher: Danielle Kaprelian Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: Burden of diverticulosis: https://www.gastrojournal.org/article/S0016-5085(09)00045-6/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F Increasing diverticulosis in young: https://doi.org/10.1007/s10620-021-06956-w Epidemiology of diverticulosis by country: https://doi.org/10.1371/journal.pone.0123688 https://pubmed.ncbi.nlm.nih.gov/23385677/ Low fiber diet and diverticulosis:  https://doi.org/10.1016/j.cgh.2013.06.033 Diverticulitis prevalence:  https://doi.org/10.1097/sla.0b013e3181952888 Diverticulitis risk factors and lifestyle: https://pubmed.ncbi.nlm.nih.gov/29112202/ Nuts, corns and popcorn- male cohort study: https://doi.org/10.1001/jama.300.8.907  Nuts, corns and popcorn- male cohort study: https://doi.org/10.7326/annals-24-03353 The DINMATO trial on antibiotic use in mild cases of diverticulitis:  https://pubmed.ncbi.nlm.nih.gov/34183510/

Many of us assume that we are visual learners, or we learn by doing or by seeing something on the printed page. Whether you've heard of it or not, the VARK system has probably influenced how you think you learn best. But it's complete pseudoscience. Katie Dyer joins to debunk one of the most long held and commonly believed pieces of misinformation out there.   JOIN OUR STUDY HERE: https://bit.ly/digitaldietstudy   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected].   Host:     Christopher Labos Editor:    Robyn Flynn Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: Pashler, H., McDaniel, M., Rohrer, D., & Bjork, R. A. (2008). Learning styles: Concepts and evidence. Psychological Science in the Public Interest, 9(3), 105–119. https://doi.org/10.1111/j.1539-6053.2009.01038.x Husmann, P. R., & O'Loughlin, V. D. (2019). Another nail in the coffin for learning styles? Disparities among undergraduate anatomy students' study strategies, class performance, and reported VARK learning styles. Anatomical Sciences Education, 12(1), 6–19. https://doi.org/10.1002/ase.1777

A viewer question asks how dangerous marathons and longer races are. Also, there is new data about coronary calcifications in marathon runners. Given that the first person to ever run a marathon dropped dead in the Agora of Athens after delivering his fateful message, there are reasons to be concerned that very long distance races are not good for you.   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected]. Hosts:     Christopher Labos & Sophie Tseng Pellar Editor:    Robyn Flynn Researcher: Auriane Journet Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: RunRepeat. The State of Ultra Running 2020. https://runrepeat.com/state-of-ultra-running  RunSignup. 2025 Ultramarathon Statistics. https://info.runsignup.com/2026/04/16/2025-ultramarathon-statistics/  Schnohr, P, O'Keefe, J, Marott, J. et al. Dose of Jogging and Long-Term Mortality: The Copenhagen City Heart Study. JACC. 2015 Feb, 65 (5) 411–419. https://doi.org/10.1016/j.jacc.2014.11.023 Pedisic, Zeljko et al. "Is running associated with a lower risk of all-cause, cardiovascular and cancer mortality, and is the more the better? A systematic review and meta-analysis." British journal of sports medicine vol. 54,15 (2020): 898-905. doi:10.1136/bjsports-2018-100493 Lee, D, Pate, R, Lavie, C. et al. Leisure-Time Running Reduces All-Cause and Cardiovascular Mortality Risk. JACC. 2014 Aug, 64 (5) 472–481. https://doi.org/10.1016/j.jacc.2014.04.058 Kim, Jonathan H et al. "Cardiac Arrest During Long-Distance Running Races." JAMA vol. 333,19 (2025): 1699-1707. doi:10.1001/jama.2025.3026 Newman, William et al. "Risk of atrial fibrillation in athletes: a systematic review and meta-analysis." British journal of sports medicine vol. 55,21 (2021): 1233-1238. doi:10.1136/bjsports-2021-103994 Videbæk S, Bueno AM, Nielsen RO, Rasmussen S. Incidence of running-related injuries per 1000 h of running in different types of runners. Sports Med. 2015;45(7):1017–1026. https://link.springer.com/article/10.1007/s40279-015-0333-8  Alentorn-Geli, Eduard et al. "The Association of Recreational and Competitive Running With Hip and Knee Osteoarthritis: A Systematic Review and Meta-analysis." The Journal of orthopaedic and sports physical therapy vol. 47,6 (2017): 373-390. doi:10.2519/jospt.2017.7137 Heikura, Ida A., Arja L.T. Uusitalo, Trent Stellingwerff, Dan Bergland, Antti A. Mero, and Louise M. Burke. "Low Energy Availability Is Difficult to Assess but Outcomes Have Large Impact on Bone Injury Rates in Elite Distance Athletes". International Journal of Sport Nutrition and Exercise Metabolism 28.4 (2018): 403-411. https://doi.org/10.1123/ijsnem.2017-0313

The term has become synonymous with ignorance, incompetence, nincompoopery, crankiness and just being dumb. But what does the Dunning-Kruger effect really mean and is it even real?? David Dunning joins to discuss how much of the popular understanding is actually evidence based.   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected]. Hosts:     Christopher Labos Editor:    Robyn Flynn Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: 1) David Dunning's presentation at LiliCon The Tricky Art of Knowing When You Really Don't Know : https://www.youtube.com/watch?v=ifjnHckelOs 2) The original 1999 paper: https://psycnet.apa.org/record/1999-15054-002 3) Other examples of the Dunning-Kruger phenomenon: https://pubmed.ncbi.nlm.nih.gov/12712114/ 4) The statistical arguments of the Dunning-Kruger effect being a statistical artefact: https://www.sciencedirect.com/science/article/abs/pii/S0160289620300271

Why is endometriosis so hard to diagnose and why do most people not really know what it is? For something so common, endometriosis is rarely talked about. Until today. Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected]. Hosts:     Christopher Labos & Sophie Tseng Pellar Editor:    Robyn Flynn Researcher: Danielle Kaprelian Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: ESHRE guideline: endometriosis https://pubmed.ncbi.nlm.nih.gov/35350465/   Time to Diagnose Endometriosis: Current Status, Challenges and Regional Characteristics-A Systematic Literature Review https://pubmed.ncbi.nlm.nih.gov/39373298/   Barriers to a Timely Diagnosis of Endometriosis: A Qualitative Systematic Review https://pubmed.ncbi.nlm.nih.gov/37441792/    Factors Associated with Time to Endometriosis Diagnosis in the United States https://pubmed.ncbi.nlm.nih.gov/28440744/    Rethinking the pathogenesis of endometriosis: Complex interactions of genomic, epigenetic, and environmental factors https://pubmed.ncbi.nlm.nih.gov/39293995/   The Immunopathophysiology of Endometriosis https://pubmed.ncbi.nlm.nih.gov/30054239/   Unus pro omnibus, omnes pro uno: A novel, evidence-based, unifying theory for the pathogenesis of endometriosis https://pubmed.ncbi.nlm.nih.gov/28571791/   Navigating towards precision: evaluating the clinical value of non-invasive biomarkers for the diagnosis of endometriosis https://pubmed.ncbi.nlm.nih.gov/38576337/   ACOG Publishes New Endometriosis Clinical Guidance, Aiming to Shorten Time to Diagnosis and Improve Access to Care https://www.acog.org/news/news-releases/2026/02/acog-publishes-new-endometriosis-clinical-guidance-aiming-shorten-time-diagnosis-improve-access-care   Diagnosis of Endometriosis https://www.acog.org/clinical/clinical-guidance/clinical-practice-guideline/articles/2026/03/diagnosis-of-endometriosis

Polycystic ovarian syndrome now has a new name, polyendocrine metabolic syndrome. But not everyone is happy. Is this progress or just a label swap? Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected]. Hosts:     Christopher Labos & Sophie Tseng Pellar Editor:    Robyn Flynn Researcher: Danielle Kaprelian Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References:   The Lancet (2026): Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process - ScienceDirect   International Evidence-Based Guideline for the Assessment and Management of PCOS: International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome 2023 - Monash University   Historical / context NIH Methodology Workshop (2012): Evidence-based Methodology Workshop on Polycystic Ovary Syndrome (PCOS) | NIH Office of Disease Prevention Website    Commentary / debate JAMA Medical News (2026): PCOS Is Now PMOS—Will a New Name Translate to Improved Clinical Care? | Reproductive Health | JAMA | JAMA Network BMJ Commentary (2026): PCOS name change to PMOS must be managed to avoid confusing patients, says expert | The BMJ   Patient-facing summaries Endocrine Society (2026): Polyendocrine Metabolic Ovarian Syndrome: New name to improve diagnosis and care of condition affecting 170 million women worldwide | Endocrine Society Yale Medicine (2026): PCOS Is Renamed PMOS: What You Need to Know | News | Yale Medicine

Protein maxxing is all the rage and the new dietary guidelines in the US recently doubled the recommended amount of protein intake. But will a high protein diet help you lose weight and will it really help you build more muscle? Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected]. Hosts:     Christopher Labos & Sophie Tseng Pellar Editor:    Robyn Flynn Researcher: Auriane Journet Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References:   Clinthorne, J., Leidy, H. J., & Sollid, K. (2026). A Modern Take on Protein Nutrition Meets Evolving Consumer Perceptions. The Journal of nutrition, 156(5), 101477. https://doi.org/10.1016/j.tjnut.2026.101477  Devries, M. C., Sithamparapillai, A., Brimble, K. S., Banfield, L., Morton, R. W., & Phillips, S. M. (2018). Changes in Kidney Function Do Not Differ between Healthy Adults Consuming Higher- Compared with Lower- or Normal-Protein Diets: A Systematic Review and Meta-Analysis. The Journal of nutrition, 148(11), 1760–1775. https://doi.org/10.1093/jn/nxy197  Hägele, F. A., Herpich, C., Koop, J., Grübbel, J., Dörner, R., Fedde, S., Götze, O., Boirie, Y., Müller, M. J., Norman, K., & Bosy-Westphal, A. (2025). Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance. Nature metabolism, 7(4), 704–713. https://doi.org/10.1038/s42255-025-01247-4 Health Canada. Canada's Dietary Guidelines for Health Professionals and Policy Makers. Government of Canada; 2019. canada.ca/en/health-canada/services/food-guide/explore/dietary-guidelines Helms, E. R., Aragon, A. A., & Fitschen, P. J. (2014). Evidence-based recommendations for natural bodybuilding contest preparation: nutrition and supplementation. Journal of the International Society of Sports Nutrition, 11, 20. https://doi.org/10.1186/1550-2783-11-20 International Food Information Council. 2025 IFIC Food & Health Survey: The Full Report. January 2026. https://ific.org/research/2025-food-health-survey Jäger, R., Kerksick, C. M., Campbell, B. I., Cribb, P. J., Wells, S. D., Skwiat, T. M., Purpura, M., Ziegenfuss, T. N., Ferrando, A. A., Arent, S. M., Smith-Ryan, A. E., Stout, J. R., Arciero, P. J., Ormsbee, M. J., Taylor, L. W., Wilborn, C. D., Kalman, D. S., Kreider, R. B., Willoughby, D. S., Hoffman, J. R., … Antonio, J. (2017). International Society of Sports Nutrition Position Stand: protein and exercise. Journal of the International Society of Sports Nutrition, 14, 20. https://doi.org/10.1186/s12970-017-0177-8 Leidy, H. J., Clifton, P. M., Astrup, A., Wycherley, T. P., Westerterp-Plantenga, M. S., Luscombe-Marsh, N. D., Woods, S. C., & Mattes, R. D. (2015). The role of protein in weight loss and maintenance. The American journal of clinical nutrition, 101(6), 1320S–1329S. https://doi.org/10.3945/ajcn.114.084038 Morton, R. W., Murphy, K. T., McKellar, S. R., Schoenfeld, B. J., Henselmans, M., Helms, E., Aragon, A. A., Devries, M. C., Banfield, L., Krieger, J. W., & Phillips, S. M. (2018). A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. British Journal of Sports Medicine, 52(6), 376–384. https://doi.org/10.1136/bjsports-2017-097608 Pasiakos SM, Davis TA, Klurfeld DM, Neuhouser ML, Rodriguez NR, Tomé D. Perspectives on the protein recommendations in the 2025-2030 Dietary Guidelines for Americans. J Nutr 2026. US Departments of Agriculture and Health and Human Services. Dietary Guidelines for Americans, 2025-2030. Wycherley TP, Moran LJ, Clifton PM, et al. Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of RCTs. Am J Clin Nutr 2012;96(6):1281-1298. doi:10.3945/ajcn.112.044321

The United States outspends every other country on Earth on healthcare but shockingly does not have the best outcomes and ranks 32nd in terms of life expectancy. Switzerland spends less and does better. Plucky little Canada ranks 22nd in the world. Kim Moon is back to explain why more spending doesn't equal better outcomes and what really drives higher health care costs. Also, a comparative analysis of the US and Canadian healthcare systems: what works and what doesn't in each country.   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected]. Hosts:     Christopher Labos & Kim Moon Editor:    Robyn Flynn Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: The richest Americans live about as long as the poorest Europeans, study says : NPR   U.S. Health Care from Global Perspective 2026 Expanded Edition | Commonwealth Fund   How does U.S. life expectancy compare to other countries? - Peterson-KFF Health System Tracker   Hospital Global Budgeting: Lessons from Maryland and Selected Nations   The U.S. Health Disadvantage and Why It Matters to Business - Community Health and Economic Prosperity - NCBI Bookshelf   Expanding healthcare capacity in Canada: the potential of internationally trained physicians - ScienceDirect   Troubling Diagnosis: Comparing Canada's Healthcare with International Peers – C.D. Howe Institute   Life expectancy at birth: Health at a Glance 2025 | OECD   Seven reasons why Americans pay more for health care than any other nation   Canada | Commonwealth Fund   State of Health Insurance Coverage in U.S.: 2024 Biennial Survey | Commonwealth Fund   Health Spending - International Comparison of Health Systems | KFF   Canadians need doctors. These strategies from around the country aim to find them | CBC News   'You Aren't Trapped': Hundreds of US Nurses Choose Canada Over Trump's America - KFF Health News   COMMENTARY: 5 affordable ways to improve Canadians' access to health care in 2026 | CMA

We're back with another review of the show that will outlive us all. Grey's Anatomy part 3 with cases like the boy who lived in a plastic bubble, the man who believed he was pregnant, the competitive eater who ate too much, the woman who felt no pain, and the patient who could hear everything during surgery.   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected]. Hosts:     Christopher Labos & Robyn Flynn Editor:    Robyn Flynn Researcher: Danielle Kaprelian Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information.

Is Bill Gates really trying to decrease the world's population by 15% using the covid vaccine? Was the gong show that is Microsoft Office just a prelude to mass genocide? What would you do if a friend forwarded you a Ted Talk of Gates claiming exactly that? Would you assume it was a deep fake or edited to misrepresent what he said or is it even more complicated than that. Floris van Vugt joins to unravel the mystery of the billionaire's bluster and tell us if indeed there are microchips in our vaccines.   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected].   Editor:    Robyn Flynn Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: Initially emailed clip Actual TED talk How does better healthcare reduce population growth? George Bernard Shaw Anti-Vax Quote

Polycystic Ovarian Syndrome has been renamed Polyendocrine Metabolic Ovarian Syndrome. So seems like a good time to review our previous episode on it as we prep for a formal update on why the name change happened. Also, we hear Danielle's voice for the first time!!   Robyn Flynn joins Chris to talk about polycystic ovarian syndrome. More common than most people realize and with more far-reaching implications than it would initially seem. It can impact fertility, cardiovascular health, and according to Robyn is more painful than childbirth?!? We're going to have to look into that one.   You can also check out Robyn's podcast, Rebel Mom Boss https://open.spotify.com/show/4uMAsJS9ySR47iGYw8ExDo?si=bc68ddfcb0bd4f3f   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected].   Editor:    Robyn Flynn Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris not your doctor (probably). This podcast is not medical advice for you; it is what we call information.   References: 1) Dutch Twin study about the role of genetics in PCOS:   10.1210/jc.2005-1494   2) Cochrane review on meds that improve fertility https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003053.pub6/full   3) RCT of diet to restore fertility https://academic.oup.com/jcem/article-abstract/88/2/812/2845309?redirectedFrom=fulltext   4) Benefits of weight loss prior to fertility treatment 10.1210/jc.2016-1659 5) Letrozole vs. clomiphene for fertility treatment https://www.nejm.org/doi/full/10.1056/NEJMoa1313517 6) Metformin as a fertility treatment 10.1001/jamanetworkopen.2020.11995

Chris and Sophie provide an update on the Enhanced Games. They happened and the story, bad enough as it was, got a little a bit worse. Go back in time with us to review why allowing athletes to dope without consequences is "a farce, an extremely dangerous one" Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected].   Hosts:     Christopher Labos & Sophie Tseng Pellar Editor:    Robyn Flynn Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information.   References: Sophie's original article on the Enhanced Games: https://www.mcgill.ca/oss/article/critical-thinking-student-contributors-health-and-nutrition/faster-higher-stronger-enhanced Popular press coverage of the games: https://www.nytimes.com/athletic/6374748/2025/05/22/enhanced-games-world-records-kristian-gkolomeev/ The story of the 15 year old Russian skater Kamila Valieva who lost her gold medal after taking trimetazidine https://www.theguardian.com/sport/2024/jan/29/russia-figure-skater-kamila-valieva-four-year-doping-ban-beijing-winter-olympics\ The TRAVERSE trial on the cardiovascular safety of testosterone https://www.nejm.org/doi/full/10.1056/NEJMoa2215025

In our first summer series episode, we review a topic that keeps coming back. Hormone therapy for menopause. It was a thing, then it stopped being a thing, now it's a thing again.   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected].   Editor:    Robyn Flynn Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References:  Geographic variability of menopausal symptoms   1) Nappi RE et al. Global cross-sectional survey of women with vasomotor symptoms associated with menopause: prevalence and quality of life burden. Menopause. 2021 May 24;28(8):875-882. doi: 10.1097/GME.0000000000001793.    2) Nappi RE, et al.  Prevalence and quality-of-life burden of vasomotor symptoms associated with menopause: A European cross-sectional survey. Maturitas. 2023 Jan;167:66-74. doi: 10.1016/j.maturitas.2022.09.006.    What's the normal duration of symptoms   3) Avis NE, et al. Study of Women's Health Across the Nation. Duration of menopausal vasomotor symptoms over the menopause transition. JAMA Intern Med. 2015 Apr;175(4):531-9. doi: 10.1001/jamainternmed.2014.8063.  The Women's Health Initiative (WHI) studies   Rossouw JE et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002 Jul 17;288(3):321-33. doi: 10.1001/jama.288.3.321.    Anderson GL et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA. 2004 Apr 14;291(14):1701-12. doi: 10.1001/jama.291.14.1701.   Decline in HRT after WHI studies   Sprague BL, Trentham-Dietz A, Cronin KA. A sustained decline in postmenopausal hormone use: results from the National Health and Nutrition Examination Survey, 1999-2010. Obstet Gynecol. 2012 Sep;120(3):595-603. doi: 10.1097/AOG.0b013e318265df42.   Danish Osteoporosis Prevention Study Schierbeck LL metal. Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial. BMJ. 2012 Oct 9;345:e6409. doi: 10.1136/bmj.e6409.   Kronos Early Estrogen Prevention Study (KEEPS) Harman SM, et al. Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial. Ann Intern Med. 2014 Aug 19;161(4):249-60. doi: 10.7326/M14-0353.   Kronos Early Estrogen Prevention Study (KEEPS) Hodis HN et al. Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol. N Engl J Med. 2016 Mar 31;374(13):1221-31. doi: 10.1056/NEJMoa1505241.    Stopping hormonal therapy   Berman RS et al. Risk factors associated with women's compliance with estrogen replacement therapy. J Womens Health. 1997 Apr;6(2):219-26. doi: 10.1089/jwh.1997.6.219.   Grady D, Sawaya GF. Discontinuation of postmenopausal hormone therapy. Am J Med. 2005 Dec 19;118 Suppl 12B:163-5. doi: 10.1016/j.amjmed.2005.09.051.   Tapering vs. abrupt stop or hormonal therapy   Haimov-Kochman R et al. Gradual discontinuation of hormone therapy does not prevent the reappearance of climacteric symptoms: a randomized prospective study. Menopause. 2006 May-Jun;13(3):370-6. doi: 10.1097/01.gme.0000186663.36211.c0. PMID: 16735933.

Susan Gerbic and the Guerilla Skepticism on Wikipedia project are trying to do the impossible. They are trying to fact check the internet. You too can join this vital work and make the internet a slightly more scientifically accurate place.     Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected]. Hosts:     Christopher Labos Editor:    Robyn Flynn Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: More on the Guerilla Skeptic project: https://www.abouttimeproject.org/ Her facebook page if you want to be in touch and join the group: https://www.facebook.com/Gerbic

Are light runs (Zone 2 runs) better than heavier workouts? Sophie goes on a semi-manic tangent in her most enthusiastic episode yet to answer whether less intense exercise might actually help your fitness level, aerobic threshold and mitochondrial efficiency. Also, Chris tells a funny marathon story and a viewer question tries to fact-check to the fact checkers on whether walking and running burn the same amount of energy.   Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at [email protected].   Hosts:     Christopher Labos & Sophie Tseng Pellar Editor:    Robyn Flynn Researcher: Auriane Journet Theme music: "Fall of the Ocean Queen" by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: 1.   Storoschuk, K. L., Moran-MacDonald, A., Gibala, M. J., & Gurd, B. J. (2025). Much Ado About Zone 2: A Narrative Review Assessing the Efficacy of Zone 2 Training for Improving Mitochondrial Capacity and Cardiorespiratory Fitness in the General Population: KL Storoschuk et al. Sports Medicine, 55(7), 1611-1624.  2.   Mølmen, K. S., Almquist, N. W., & Skattebo, Ø. (2025). Effects of exercise training on mitochondrial and capillary growth in human skeletal muscle: a systematic review and meta-regression. Sports Medicine, 55(1), 115-144. 3.   Inglis, E. C., Iannetta, D., Rasica, L., Mackie, M. Z., Keir, D. A., Macinnis, M. J., & Murias, J. M. (2024). Heavy-, severe-, and extreme-, but not moderate-intensity exercise increase V̇o 2max and thresholds after 6 wk of training. Medicine & Science in Sports & Exercise, 56(7), 1307-1316. 4.   McConell, G.K., Wadley, G.D., Le plastrier, K. and Linden, K.C. (2020), Skeletal muscle AMPK is not activated during 2 h of moderate intensity exercise at ∼65% in endurance trained men. J Physiol, 598: 3859-3870. https://doi.org/10.1113/JP277619 5.   Meixner, B., Filipas, L., Holmberg, H. C., & Sperlich, B. (2025). Zone 2 Intensity: A Critical Comparison of Individual Variability in Different Submaximal Exercise Intensity Boundaries. Translational sports medicine, 2025, 2008291. https://doi.org/10.1155/tsm2/2008291 6.   Harber MP, et al. Impact of Cardiorespiratory Fitness on All-Cause and Disease-Specific Mortality: Advances Since 2009. Progress in Cardiovascular Diseases 2017;60(1):11-20. PubMed 28286137 7.   Kodama S, Saito K, Tanaka S, et al. Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women: A Meta-analysis. JAMA 2009;301(19):2024-2035. PubMed 19454641