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Fatty Pancreas and Risk of Type 2 Diabetes, Chronic Kidney Disease and Cardiovascular Events: Evidence From a Population-Based Cohort https://onlinelibrary.wiley.com/doi/10.1002/ueg2.70253 Eosinophilic Esophagitis and Autoimmune Thyroid Disease: A Population-Based Matched Cohort Study https://onlinelibrary.wiley.com/doi/10.1002/ueg2.70248 Cohort Study: Risk of Gallstones and Biliary Complications With Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes https://onlinelibrary.wiley.com/doi/10.1002/ueg2.70238 Rising Burden and Clinical Impact of Metabolic Syndrome in Inflammatory Bowel Disease: A Real-World Cohort Study https://onlinelibrary.wiley.com/doi/full/10.1002/ueg2.70255

Key takeaway messages 1. Salivary molecular signatures may offer a non-invasive way to detect gastric cancer, with SLC5A5 emerging as a promising biomarker. 2. Real-world registry data show upadacitinib to be effective and generally safe in patients with Crohn’s disease, supporting its use beyond clinical trials. 3. Endoscopic ultrasound-guided gastroenterostomy demonstrates better cost-effectiveness compared with surgical gastrojejunostomy in a randomized health-economic analysis.

European Guideline on Pre-Operative Prevention of Surgical Site Infections Following Digestive Surgery: A Joint Update of the WHO SSI Guideline for Gastrointestinal Surgery by UEG, ESCP, EAES, and SIS-E DOI: https://doi.org/10.1002/ueg2.70128

Associate Editor Daniel Keszthelyi discusses the importance of robust research methodology, negative trials, and the effects of transcutaneous auricular vagal nerve stimulation on chronic constipation, alongside a farewell from Editor-in-Chief Albrecht Neesse.

Study Title: Combined analysis of a serum mRNA/miRNA marker signature and CA 19-9 for timely and accurate diagnosis of recurrence after resection of pancreatic ductal adenocarcinoma: A prospective multicenter cohort study Link: https://onlinelibrary.wiley.com/doi/10.1002/ueg2.12676 Guest: Professor Malte Buchholz

1. Featuring: KPIs in EGD, Rifaximin-α for HE, Updated Dysphagia Guidelines, AI in Endoscopy, and MSK Injuries in Endoscopists DOI: https://doi.org/10.1002/ueg2.70001 2.Rifaximin-α in Patients With Recurrent Episodes of Hepatic Encephalopathy Due to Cirrhosis Reduces Healthcare Utilization DOI: https://doi.org/10.1002/ueg2.12767 3. Esophageal and Oropharyngeal Dysphagia: Clinical Recommendations From the United European Gastroenterology and European Society for Neurogastroenterology and Motility DOI: https://doi.org/10.1002/ueg2.70062 4. Challenges in Implementing Endoscopic Artificial Intelligence: The Impact of Real-World Imaging Conditions on Barrett's Neoplasia Detection DOI: https://doi.org/10.1002/ueg2.12760 5. Endoscopy-Related Musculoskeletal Injuries: A Systematic Review and Meta-Analysis on Prevalence, Risk Factors and Prevention DOI: https://doi.org/10.1002/ueg2.70042

1. Concomitant Use of Etrasimod With Opioids or Antidepressants in Patients With Ulcerative Colitis—A Safety Analysis https://onlinelibrary.wiley.com/doi/10.1002/ueg2.12745 https://doi.org/10.1002/ueg2.12745 2.Multiple Concomitant Precipitating Factors of Hepatic Encephalopathy Are Associated With a Poor Prognosis in Patients With Cirrhosis Admitted to Intensive Care Unit https://onlinelibrary.wiley.com/doi/10.1002/ueg2.12706 https://doi.org/10.1002/ueg2.12706 3. Duodenal Laser Ablation for Treatment of Type 2 Diabetes: Results of First in Human Study https://onlinelibrary.wiley.com/doi/10.1002/ueg2.12762 https://doi.org/10.1002/ueg2.12762 4. Chronic Kidney Disease Increases Risk of Delayed Post-Polypectomy Bleeding: A Large-Scale Propensity Score-Matched Analysis https://onlinelibrary.wiley.com/doi/10.1002/ueg2.70013 https://doi.org/10.1002/ueg2.70013

GI pearls from the latest literature published in UEGJ

Ahsen Ustaoglu interviews Dr Celia Escudero-Hernandez on their transcriptomic study delving into the pathogenesis of lymphocytic colitis, where they identified two subtypes of lymphocytic colitis: channelopathic and inflammatory lymphocytic colitis, which could pave the way for novel biomarkers and therapeutic avenues.