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Solving the Puzzle with Dr. Datis Kharrazian

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Rating
★★★★★
4.9
from
101 reviews
This podcast has
113 episodes
Language
English
Date created
2021/07/01
Latest episode
2026/11/04
Average duration
30 min.
Release period
6 days

Description

Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases. Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases.  His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life. Hashimoto's: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto's hypothyroidism. This course has the most complete and current information for managing Hashimoto's available. You can find more information at drknews.com. Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

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Episode 112: How Chronic Stress Worsens Eczema
2026/11/04
Chronic stress doesn’t just affect mood. It drives inflammation that can make atopic dermatitis worse. This episode explains how stress signals travel through the nervous system to the skin, how polyvagal theory helps us understand a child’s stress state, and why co-regulation is one of the most powerful tools for calming both behavior and eczema. Enroll now in: Pediatric Health from the Womb and Beyond, with Chris Magryta, MD ⚡ A Kharrazian Institute Master Class at https://pages.kharrazianinstitute.com/magryta-pediatric-health Practitioners can start a free 7-day trial at kharrazianinstitute.com TIMESTAMPS: 00:00 Understanding Stress and Skin Health 05:30 The role of the vagus nerve 08:52 Understanding co-regulation and perception 11:58 Addressing Behavioral Challenges in Kids 13:56 Understanding Children's Behavior Responses 17:57 Building a strong developmental foundation 21:36 Importance of practitioner mindset 22:23 Podcast resources and disclaimers Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 111: The Anti-inflammatory Powers of Short Chain Fatty Acids
2026/10/28
Dr. Datis Kharrazian explains short-chain fatty acids and the postbiotics your gut bacteria make from fiber. He covers how butyrate calms inflammation, repairs leaky gut, and supports immune tolerance, while acetate and propionate help with blood sugar, satiety, and GLP-1. He also discusses LPS and endotoxemia, why butyrate can help people with SIBO or dysbiosis, how to dose it, and where probiotics fit in. Interviewed by Elaine Marshall. Want the most comprehensive functional medicine training? Start your seven-day free trial at kharrazianinstitute.com and access over 300 hours of clinical training with Dr. Kharrazian and leading functional medicine clinicians. If you're not a clinician, look for functional medicine patient courses at drknews.com TIMESTAMPS: 00:00 Discussing butyrate supplements and dosage 05:13 Benefits of butyrate for gut health 07:17 Role of LPS in inflammation 10:48 Starting butyrate supplementation 13:53 Teaching seminars and butyrate insights 17:20 Flaws in microbiome research 22:12 Understanding gut health supplements 23:34 Understanding microbiome and diet diversity 27:16 Health advice disclaimer Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 110: Migraines and Brain Injury
2026/10/26
Migraines are more than bad headaches. Migraine attacks trigger inflammation and reduce blood flow in the brain, leading to white matter lesions and higher risks of stroke and Alzheimer’s disease. Datis Kharrazian explains how rising migraine frequency is a red flag, how conventional treatment works, and how a functional medicine approach targets triggers like hormone imbalances, insulin resistance, allergies, and poor sleep. Supplements covered include magnesium, vitamin D, omega-3s, CoQ10, and riboflavin. Interviewed by Elaine Marshall. Want the most comprehensive functional medicine training? Start your seven-day free trial at kharrazianinstitute.com and access over 300 hours of clinical training with Dr. Kharrazian and leading functional medicine clinicians. If you're not a clinician, look for functional medicine patient courses at drknews.com TIMESTAMPS: 00:00 Brain inflammation and MRI spots 08:24 How migraines trigger pain 14:06 Using migraine tracking apps 15:55 Link between obesity and migraines 18:30 Managing migraines with supplements 22:05 Functional medicine and migraine triggers 28:15 Understanding headaches vs. migraines 32:00 Role of adrenal glands in health 35:04 Exploring training and certification options Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 109: Leaky Gut & LPS: What Every Practitioner Should Know
2026/10/21
In this episode, Dr. Liz Lipski covers what drives intestinal permeability, how LPS affects inflammation, autoimmunity, the brain, and the skin, which tests are most useful, and practical healing strategies like glutamine, zinc carnosine, quercetin, demulcents, and bone broth. Enroll now in: Insights into Digestive Wellness, with Liz Lipski, PhD, FACN, CNS, IFMCP A Kharrazian Institute Master Class at https://pages.kharrazianinstitute.com/lipski-digestive-wellness Practitioners can start a free 7-day trial at kharrazianinstitute.com TIMESTAMPS: 00:00 Understanding brush borders and zonulin 04:15 Causes of leaky gut 08:13 Causes of celiac disease 12:11 Understanding leaky gut and its tests 13:56 Testing lactulose and mannitol molecules 19:46 Gut health and soothing remedies 21:17 Podcast closing and resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 108: Digestive Wellness with Dr. Liz Lipski
2026/10/14
Dr. Liz Lipski discusses how to choose the right elimination diet for each patient, why gut healing should be temporary, how resilient the microbiome really is, GLP-1s and Akkermansia, and which gut tests are actually useful. Enroll now in: Insights into Digestive Wellness, with Liz Lipski, PhD, FACN, CNS, IFMCP A Kharrazian Institute Master Class at https://pages.kharrazianinstitute.com/lipski-digestive-wellness Practitioners can start a free 7-day trial at kharrazianinstitute.com TIMESTAMPS: 0:00 Introduction & the early days of functional nutrition 4:30 Gaps in medical training & "when in doubt, start with the gut" 7:00 Choosing the right elimination diet 10:30 Carnivore, SIBO & resetting the microbiome 14:00 FODMAP reintroduction & the big three: dairy, eggs, gluten 16:00 Elimination diets, orthorexia & disordered eating 19:30 GLP-1s, Akkermansia & satiety 23:00 What gut testing is actually useful 26:00 Comparing stool tests & final thoughts 29:00 Closing Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 107: Digestive Enzymes and the Overlooked Signs of Pancreatic Insufficiency
2026/10/07
Liz Lipski breaks down the three main types of digestive enzymes, how to test for pancreatic exocrine insufficiency using fecal elastase, and how to choose the right product for each patient. She walks through prescription options, full spectrum supplements, lipase-loaded formulas, and food-based sources, and explains why pancreatic insufficiency is so commonly missed because it presents exactly like IBS. Enroll now in: Insights into Digestive Wellness, with Liz Lipski, PhD, FACN, CNS, IFMCP at https://pages.kharrazianinstitute.com/lipski-digestive-wellness TIMESTAMPS: 00:00 Understanding Pancreatic Conditions 04:00 Testing for enzyme deficiency 07:13 Digestive enzymes and medical use 10:34 Protease enzymes and sensitivities 14:23 Digestive enzymes and their benefits 19:22 Enzyme naming and sensitivity options 23:15 Promoting resources for practitioners 24:13 Consult Your Healthcare Provider Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 106: Ferritin, Iron Deficiency & Iron Overload
2026/09/30
Ferritin is one of the most misunderstood markers on a blood test. A low-normal result doesn’t automatically mean iron deficiency, and an elevated result doesn’t necessarily mean iron overload. In this episode, Dr. Datis Kharrazian explains how ferritin reflects iron storage and inflammation, why unnecessary iron supplementation can create problems, and which tests offer clearer answers. Interviewed by Elaine Marshall. Want the most comprehensive functional medicine training? Start your seven-day free trial at kharrazianinstitute.com and access over 300 hours of clinical training with Dr. Kharrazian and leading functional medicine clinicians.  If you're not a clinician, look for functional medicine patient courses at drknews.com. TIMESTAMPS:  00:00 Iron absorption and aging challenges 03:56 Misinterpreting Ferritin Levels 07:49 Understanding ferritin and hemochromatosis 13:07 Understanding health risks for MS patients 15:47 Iron storage depletion explained 17:25 Managing iron deficiency and inflammation 20:39 How the body processes iron 25:51 Learning from Christy Sutton's insights 28:09 Importance of Blood Chemistry Analysis 30:32 Promoting educational resources and courses Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 105: The Future of AI in Clinical Practice
2026/09/23
Sunjya Schweig looks at where AI in clinical practice is headed over the next one to three years, from AI native EMRs and ambient scribing to fully integrated clinical copilots that surface real time insights and automate routine tasks. He outlines what practitioners who build fluency now will have over those who wait, why the skill advantage compounds over time, and how to stay current without drowning in information overload.  Enroll now in: Clinical Applications of AI: A Competency-Based Masterclass for Integrative and Functional Medicine Practitioners, with Sunjya Schweig, MD at https://pages.kharrazianinstitute.com/schweig-ai-functional-medicine   TIMESTAMPS:  00:00 Discussing future AI developments 03:23 Automating patient intake with AI 09:09 AI streamlining healthcare decisions 10:57 Building expertise through micro-learning 16:45 AI fluency and customization in practice 18:53 Organizing and building with platforms 21:21 Closing and resources mention Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 107: AI in a functional medicine - with Dr. Sunjya Schweig
2026/09/22
Dr. Sunjya Schweig explains how AI is changing day-to-day clinical work in functional medicine. He walks through his clinic's HIPAA-compliant Claude setup and the workflow he uses to compare answers across multiple LLMs. He also makes the case for practitioners to move beyond simply querying ChatGPT and build curated AI knowledge bases for specific chronic-health protocols, patient onboarding, and other recurring clinical tasks. The conversation also covers the tensions of this transitional period. Patients now arrive at appointments with their own AI assistants, and insurance company bots are squaring off against practitioner automation. Dr. Schweig also discusses why the future of medicine may require more in-person connection, not less. Sunjya K. Schweig, MD, is an expert in complex chronic illnesses that require rigorous investigation and management. He has studied, taught, and practiced integrative and functional medicine for over 25 years. He founded and leads the California Center for Functional Medicine (CCFM). Timestamps: 0:00 Intro 0:27 Interview Begins 0:55 Dr. Schweig's Background 3:04 AI Hype vs. Doom 3:51 AI in Functional Medicine 6:13 Building Knowledge Bases 8:59 Patient-Facing AI 11:51 Quality of FM Info in LLMs 15:20 The Human Element 20:46 From Consumer to Producer 24:55 Mold Project Example 29:45 Marketing with AI 34:28 Insurance & AI Battles 36:35 Younger Generation & AI 37:05 Hiring AI Help 39:06 Closing Thoughts 41:21 Outro Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 104: The Next Frontier of AI in Functional Medicine
2026/09/16
In this podcast Sunjya Schweig breaks down what AI agents actually are, how they differ from standard chat tools, and what they can realistically do in a clinical setting right now. He walks through the main platforms, real world use cases, and the safety protocols every practitioner needs to understand before giving an agent access to anything in their workflow.  Enroll now in: Clinical Applications of AI: A Competency-Based Masterclass for Integrative and Functional Medicine Practitioners, with Sunjya Schweig, MD at https://pages.kharrazianinstitute.com/schweig-ai-functional-medicine  TIMESTAMPS:  00:00 AI personal agents and automation tools 06:25 Using cloud-based sandbox VMs 09:07 Agentic workflow and approvals 11:39 Using AI to find specialists 13:49 Understanding AI Agents and Use Cases 18:18 Resources for Healthcare Practitioners and Patients Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 103: Seed Oils Explained: Separating Oxidized Cooking Oils from Essential Fatty Acids
2026/09/09
Seed oils have become a nutritional villain, but the real issue is more specific: oxidation. In this episode, Dr. Datis Kharrazian explains why heat and light can damage unstable oils, while cold-pressed options such as flaxseed, evening primrose, and black currant oil can provide essential fatty acids the body can’t make. This conversation covers omega-3, omega-6, and omega-9 pathways, prostaglandins, insulin resistance, fatty liver, ketogenic diets, and brain health. You’ll also hear how to distinguish a beneficial oil from a rancid one, why olive oil and ghee are useful for cooking, and why blanket statements about all seed oils miss the biology. Want to go deeper? Start your seven-day free trial at kharrazianinstitute.com and access over 300 hours of clinical training with Dr. Kharrazian and leading functional medicine clinicians.  TIMESTAMPS:  00:00 Discussion about seed oils and health 05:21 Identifying Essential Fatty Acid Imbalances 07:42 Benefits of different cooking oils 10:09 Health benefits of fatty acids 15:26 Managing Fatty Acid Intake 16:35 Understanding prostaglandins and inflammation 21:23 Healthy vs Unhealthy Keto Diets 23:19 Comparing fish oils and flaxseed 26:25 Benefits of ketogenic diet for brain 29:28 Consulting your healthcare provider Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 102: Using AI to Build Practical Functional Medicine Care Plans
2026/09/02
AI can process enormous amounts of clinical information in seconds, but it has never seen a patient, built a clinical relationship, or developed clinical judgment through experience. This episode examines how AI can support treatment planning without replacing the clinician’s reasoning. Enroll now in: Clinical Applications of AI: A Competency-Based Masterclass for Integrative and Functional Medicine Practitioners, with Sunjya Schweig, MD at https://pages.kharrazianinstitute.com/schweig-ai-functional-medicine  TIMESTAMPS:  00:00 Analyzing sleep data with custom GPT 03:05 Iterative refinement with AI 07:34 Creating a Fast Food Diet Plan 10:30 Evaluating AI in Clinical Diagnosis 16:23 AI's impact on clinical expertise 20:06 AI error vigilance in clinical notes 22:27 Discussing AI in clinical practice 25:26 Outro and resources for listeners Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 101: Navigating Functional Medicine in a Small Town with Dr. Edling
2026/08/26
In today’s Practitioner Spotlight, we speak with Dr. Edling, a seasoned chiropractor and functional medicine practitioner from the small town of Osceola, Wisconsin. With over 20 years of experience integrating functional medicine into a rural practice, he shares the unique challenges and rewards of serving a close-knit community with limited resources, from adapting care to meet patients’ financial constraints to the importance of ongoing learning and genuine relationships. Interviewed by Elaine Marshall. Want the most comprehensive functional medicine training? Start your seven-day free trial at kharrazianinstitute.com and access over 300 hours of clinical training with Dr. Kharrazian and leading functional medicine clinicians.  If you're not a clinician, look for functional medicine patient courses at drknews.com. TIMESTAMPS:  00:00 Chiropractic and functional medicine journey 05:03 Mentoring young football coaches 06:37 Candidate selection and burnout discussion 10:03 Functional neurology focus and family 15:45 Discussing patient follow-through and rehab 18:32 Reflecting on Krause Experiences 21:01 Explaining the upstream health model 24:08 Family vacation and gluten challenge 26:59 Helping patients with financial struggles 32:43 Focus on personal health and fitness 35:07 Recovering from a major accident 39:27 Collaborating with Committed Clients 43:10 Encouragement for practitioners 45:33 Outro and program offerings Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 100: Understanding GLP-1 Risks: Navigating the Complexities of Weight Loss Medications
2026/08/24
GLP-1 medications, widely celebrated for their ability to break the cycle of metabolic syndrome, obesity, and diabetes, are not without risks and lesser-known downsides. Dr. Kharrazian explains the long-term effects of a constant catabolic state, including its impact on muscle mass, digestion, motivation, and overall longevity. Interviewed by Elaine Marshall. Want the most comprehensive functional medicine training? Start your seven-day free trial at kharrazianinstitute.com and access over 300 hours of clinical training with Dr. Kharrazian and leading functional medicine clinicians.  If you're not a clinician, look for functional medicine patient courses at drknews.com. TIMESTAMPS:  00:00 Impact of GLP-1s on Recovery 06:44 Importance of antioxidants for longevity 08:46 Impact of GLP-1 on Digestion 13:53 Impact of GLP-1s on Sleep 16:23 Challenges in hormonal health 18:40 Breaking the sugar-craving cycle 21:57 Preventing Muscle Loss While Fasting 27:55 Understanding SIBO and gut health 31:13 Galleri and cancer screening tests 33:43 Psychological impacts of body image 34:58 Insulin's Role in Autoimmune Response 38:02 Consult Your Healthcare Provider Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
Episode 99: Rewiring Unhealthy Behaviors in Functional Medicine
2026/08/14
Today, David Musnick dives into the science and art of assessing and changing health habits. From identifying the unconscious routines that sabotage our wellness to learning practical strategies for breaking unhealthy patterns and stacking new positive behaviors, this episode guides practitioners and patients alike through the step-by-step process of lasting habit transformation. We explore powerful tools like environmental modifications, emotional awareness, tapping techniques, and structured rewards, plus, learn how mindset and self-talk play a pivotal role in overcoming obstacles and reaching health goals.  Enroll now in: Attitudes, Limbic System, and Mind-Body Influence on Functional Medicine Outcomes, with David Musnick, MD at https://pages.kharrazianinstitute.com/musnick-mind-body TIMESTAMPS:  00:00 Identifying unhealthy habits 04:38 Discussing bad habits and solutions 07:41 Suggesting healthier morning routines 11:50 Identifying emotions to break habits 14:50 Using tapping and NLP for change 17:36 Establishing Healthy Habits with Rewards 19:16 Visualizing obstacles and successes 24:23 Nighttime eating and emotional triggers 27:11 Applying habits to health 28:45 Promoting health courses and resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

Podcast reviews

Read Solving the Puzzle with Dr. Datis Kharrazian podcast reviews


4.9 out of 5
101 reviews
★★★★★
lam19@@ 2024/06/18
My Best Health Resource!!
I listen to this podcast all the time, it is the best way to consume the most information to help your healing. Today I was looking for guidance to na...
★★★★★
K Car1234 2023/05/11
🌟🌟🌟🌟🌟 Stars!
Dr. K is sharing such solid well researched information. I am always confident about the information I receive here as being accurate. Thank you. ...
★★★★★
whisper56 2022/08/21
One of my favorites
Fantastic info!
★★★★★
Cindy Syy 2022/04/03
Fabulous Doctor- incredibly knowledgeable
I have learned more from this Doctor that all over 20 Doctors I’ve seen in the past 25 years! Thank you Dr. Datis, I’m looking forward to looking at s...
★★★★★
hfdjksdf 2021/09/22
Dr. K is a life saver
Legit the smartest doctor in the country
★★★★★
mecjb 2021/08/07
Excellent presentations
Dr K provides easy to understand information on causes, symptoms, testing and remedies. Excellent, concise information!!
★★★★★
Iva Peck 2021/08/06
My Hashimoto’s journey !
2002 was when I first manifested hypothyroid symptoms ….. fatigue, hairloss, brain fog, depression ,anxiety, digestive issues. Two endocrinologists an...
check all reviews on apple podcasts

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