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In this episode of the SREI Landmark Articles Podcast, we explore the landmark randomized controlled trials evaluating operative laparoscopy for endometriosis-associated infertility. Together, we discuss what these studies tell us, where uncertainty remains, and how to translate the evidence into patient-centered counseling about surgery and fertility optimization.

In this episode of the SREI Landmark Articles Podcast, we sit down with Dr. Heather Hipp, whose clinical and research expertise focuses on premature ovarian insufficiency (POI), and Dr. Jacqueline Phoenix, a physician who shares her personal experience with this diagnosis. Together, we explore how to counsel patients about fertility, hormone therapy, long-term health, and the uncertainty that often accompanies a POI diagnosis.

Welcome back to the SREI Landmark Articles Podcast! In this episode, our hosts David Boedeker, Ali Herweck, Kiley Hunkler, and Carissa Pekny take a closer look at the Endometrial Receptivity Analysis (ERA) and the evidence behind personalized embryo transfer. We review two landmark studies evaluating whether endometrial receptivity testing can identify a personalized window of implantation and, most importantly, whether using ERA to guide embryo-transfer timing actually improves reproductive outcomes. Along the way, we break down the study designs, key statistical concepts, clinical outcomes, and what the evidence means for counseling patients considering ERA testing. PMID: 32723696 PMID: 36472596

Welcome back to the second episode of the SREI Landmark Articles Podcast! In this episode, our hosts David Boedeker, Ali Herweck, Kiley Hunkler, and Carissa Pekny review of Doyle et al.’s 2016 retrospective cohort study on elective and medically indicated oocyte vitrification for autologous IVF. This episode examines the study’s key statistical concepts and clinical outcomes, including how age at retrieval and the number of cryopreserved mature oocytes influence predicted live-birth probability and inform fertility-preservation counseling. PMID: 26604065

Welcome to the first episode of the SREI Landmark Articles Podcast! In this episode, our hosts David Boedeker, Ali Herweck, Kiley Hunkler, and Carissa Pekny review two landmark randomized trials evaluating vaginal progesterone for miscarriage prevention: the PROMISE and PRISM trials. We discuss the clinical questions each study addressed, including progesterone use in women with recurrent miscarriage and those presenting with early pregnancy bleeding. We break down the study designs, key outcomes, and how the findings shaped current counseling around progesterone supplementation in early pregnancy. Finally, we explore the practical implications for reproductive endocrinology, obstetrics, and patient-centered care when discussing progesterone treatment with patients at risk for pregnancy loss. PROMISE: PMID 26605928 PRISM: PMID 31067371